Furin Cleavage Bioinformatics
- Analyze furin cleavage sites in protein sequences from different organisms: mammal, bactria and virus, and investigate biology of furin substrates
- Develop database and computational tools for furin cleavage
- Study molecular mechanism of furin cleavage associated human diseases, design drugs targeting proteolytic cleavage of furin and other proprotein convertases
Furin Reference (from 2008-2011 collaborated with South China University of Technology)
I am a bioinfomratics scientist at Carbon Logic Biotech(HK) Ltd. My work mainly focuses on target discovery/target validation/biomarker of immunotherapy and colorectal cancer.
Publications and patents see
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Sun Tian, Wang Huajun, Jianhua Wu. (2012) Computational prediction of furin cleavage sites by a hybrid method and understanding mechanism underlying diseases. Scientific Reports. 2, 261.
1. PiTou Furin cleavage site computational prediction tool download guide (excutable file on Windows platform): download
Sun Tian, Qingsheng Huang, Ying Fang, Jianhua Wu. (2011)
FurinDB: a database of 20-residue furin cleavage site motifs, substrates and their associated drugs.
International Journal of Molecular Sciences., 12, 1060-1065.
Sun Tian and Wu Jianhua. (2010)
Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors.
International Journal of Biological Sciences., 2010, 6, 89-95.
Multiple sequence alignment of the binding pockets of mammalian proprotein convertases :
Sun Tian. (2009)
A 20 Residues Motif Delineates the Furin Cleavage Site and its Physical Properties May Influence Viral Fusion.
Biochemistry Insights., 2, 9-20.
List of all correlation coefficient R > 0.65 in region P14--P6' on the Furin cleavage site motif: